188978-02-1
Chemical Structure
DMP-851
- CAS No.: 188978-02-1
- Formula:C31H37N5O3
- Molecular Weight:527.66
IUPAC Name: (4R,5S,6S,7R)-1-((3-amino-1H-indazol-5-yl)methyl)-4,7-dibenzyl-3-butyl-5,6-dihydroxy-1,3-diazepan-2-one
InChIKey: CGEJBZXGNPASAG-GKQHHHCTSA-N
SMILES: O=C1N(CC2=CC3=C(NN=C3N)C=C2)[C@H](CC4=CC=CC=C4)[C@H](O)[C@@H](O)[C@@H](CC5=CC=CC=C5)N1CCCC
Biological Activity: DMP-851 is a cyclic urea HIV protease inhibitor, with a Ki of 0.021 nM. DMP-851 shows antiviral activity against laboratory strains of HIV-l and HIV-2 as well as against primary clinical isolates derived from Zidovudine (HY-17413)-resistant samples (A018C, E, WR 10983)[1].
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DMP-851 | DMP-851 is a cyclic urea HIV protease inhibitor, with a Ki of 0.021 nM. DMP-851 shows antiviral activity against laboratory strains of HIV-l and HIV-2 as well as against primary clinical isolates derived from Zidovudine (HY-17413)-resistant samples (A018C, E, WR 10983). | |||||||||||||||||||||
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Keywords
