189015-24-5
Chemical Structure
TRK-851
- CAS No.: 189015-24-5
- Formula:C29H29FN2O3
- Molecular Weight:472.55
IUPAC Name: (4bS,8R,8aR,16bR)-7-(cyclopropylmethyl)-11-fluoro-5,6,7,8,9,14,15,16b-octahydro-8aH,13H-4,8-methanobenzofuro[2,3-a]dipyrido[4,3-b:3',2',1'-jk]carbazole-1,8a-diol
InChIKey: TYHUVMCMIRSIAI-KZNIJNHCSA-N
SMILES: O[C@]12[C@]34[C@](OC5=C(O)C=CC(C[C@@]2([H])N(CC4)CC6CC6)=C53)([H])C7=C(C8=CC(F)=CC9=C8N7CCC9)C1
Biological Activity: RK-851 is a highly selective and orally active δ-opioid receptor antagonist, with a negative logarithm of the antagonist concentration (pA2) of 8.84. TRK-851 exhibits the selectivity for the δ receptor of more than 100 times higher than that for the μ or κ receptors. TRK-851 exhibits a potent antitussive effect in a rat model of capsaicin-induced cough. TRK-851 can be used for research on antitussive effects[1].
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TRK-851 | RK-851 is a highly selective and orally active δ-opioid receptor antagonist, with a negative logarithm of the antagonist concentration (pA2) of 8.84. TRK-851 exhibits the selectivity for the δ receptor of more than 100 times higher than that for the μ or κ receptors. TRK-851 exhibits a potent antitussive effect in a rat model of capsaicin-induced cough. TRK-851 can be used for research on antitussive effects. | |||||||||||||||||||||
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Keywords
