189940-24-7
Chemical Structure
Mesopram
Synonym(s): Daxalipram
- CAS No.: 189940-24-7
- Formula:C14H19NO4
- Molecular Weight:265.30
IUPAC Name: (R)-5-(4-methoxy-3-propoxyphenyl)-5-methyloxazolidin-2-one
InChIKey: PCCPERGCFKIYIS-AWEZNQCLSA-N
SMILES: O=C1O[C@](C)(C2=CC=C(OC)C(OCCC)=C2)CN1
Biological Activity: Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) (HY-116282C)-induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases[1][2].
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Mesopram | 98.80% | Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) (HY-116282C)-induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases. | ||||||||||||||||||||
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- [1]. Blednov YA, et al. Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129. [Content Brief]
- [2]. Loher F, et al. The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J Pharmacol Exp Ther. 2003 May;305(2):549-56. [Content Brief]
Keywords
