189954-93-6
189954-93-6
Chemical Structure
COX-2-IN-36
- CAS No.: 189954-93-6
- Formula:C17H22O5S
- Molecular Weight:338.42
IUPAC Name: (S)-5-ethyl-3-isopropoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one
InChIKey: FZYAFLPJDVKKQI-KRWDZBQOSA-N
SMILES: CC(C)OC1=C(C2=CC=C(C=C2)S(C)(=O)=O)[C@@](C)(OC1=O)CC
Biological Activity: COX-2-IN-36 (compound 1) is a very potent and specific COX-2 inhibitor, with an IC50 of 0.4 μM[1][2].
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COX-2-IN-36 | COX-2-IN-36 (compound 1) is a very potent and specific COX-2 inhibitor, with an IC50 of 0.4 μM. | |||||||||||||||||||||
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References
- [1]. Lushi Tan, et al. Practical enantioselective synthesis of a COX-2 specific inhibitor. Tetrahedron Volume 58, Issue 37, 9 September 2002, Pages 7403-7410.
- [2]. Yves Leblanc, et al. Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20. [Content Brief]
