191744-13-5
Chemical Structure
CX614
- CAS No.: 191744-13-5
- Formula:C13H13NO4
- Molecular Weight:247.25
IUPAC Name: 2,3,6a,7,8,9-hexahydro-11H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11-one
InChIKey: RQEPVMAYUINZRE-UHFFFAOYSA-N
SMILES: O=C1C2=CC3=C(C=C2OC4N1CCC4)OCCO3
Biological Activity: CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CX614 | 99.94% | CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105. [Content Brief]
- [2]. Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970(1-2):221-5. [Content Brief]
Keywords
