1918142-35-4
1918142-35-4
Chemical Structure
CFTR corrector 8
- CAS No.: 1918142-35-4
- Formula:C29H27F2NO7
- Molecular Weight:539.52
IUPAC Name: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-((2S,4S)-2-(3,4-dimethoxyphenyl)-7-methoxychroman-4-yl)cyclopropane-1-carboxamide
InChIKey: KDOQEEMQPHIANX-REWPJTCUSA-N
SMILES: COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC
Biological Activity: CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CFTR corrector 8 | 95.86% | CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. [Content Brief]
Keywords
