1934-21-0
Chemical Structure
Tartrazine
Synonym(s): Acid Yellow 23; FD&C Yellow No. 5
- CAS No.: 1934-21-0
- Formula:C16H9N4Na3O9S2
- Molecular Weight:534.36
IUPAC Name: sodium 5-oxo-1-(4-sulfonatophenyl)-4-((4-sulfonatophenyl)diazenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate
InChIKey: UJMBCXLDXJUMFB-UHFFFAOYSA-K
SMILES: O=C(C(C1N=NC2=CC=C(S(=O)(O[Na])=O)C=C2)=NN(C3=CC=C(S(=O)(O[Na])=O)C=C3)C1=O)O[Na]
Biological Activity: Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity[1][2][3][4][5][6][7][8][9][10][11].
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Tartrazine | 99.78% | Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity. | ||||||||||||||||||||
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Tartrazine (Standard) | ≥98% | Tartrazine (Standard) is the analytical standard of Tartrazine. This product is intended for research and analytical applications. Tartrazine is an azo acid dye, orange-yellow powder, soluble in water and turns yellow. It is mainly used as a synthetic lemon yellow azo dye for food coloring. It is the most stable colorant. | ||||||||||||||||||||
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- [1]. Dos Santos JR, et al. Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells. BMC Pharmacol Toxicol. 2022 Dec 23;23(1):95. [Content Brief]
- [2]. Khayyat L, et al. Tartrazine induces structural and functional aberrations and genotoxic effects in vivo. PeerJ. 2017 Feb 23;5:e3041. [Content Brief]
- [3]. Patterson RM, et al. Tartrazine-induced chromosomal aberrations in mammalian cells. Food Chem Toxicol. 1982 Aug;20(4):461-5. [Content Brief]
- [4]. Atlı Şekeroğlu Z, et al. Effects of tartrazine on proliferation and genetic damage in human lymphocytes. Toxicol Mech Methods. 2017 Jun;27(5):370-375. [Content Brief]
- [5]. Demirkol O, et al. Oxidative effects of Tartrazine (CAS No. 1934-21-0) and New Coccin (CAS No. 2611-82-7) azo dyes on CHO cells. Journal für Verbraucherschutz und Lebensmittelsicherheit, 2012, 7: 229-236.
- [6]. Visweswaran B, et al. Oxidative stress by tartrazine in the testis of Wistar rats. Journal of Pharmacy and Biological Sciences, 2012, 2(3): 44-49.
- [7]. Ali F A, et al. Toxicological and histopathological studies on the effect of tartrazine in male albino rats. International Journal of Pharmacological and Pharmaceutical Sciences, 2016, 10(8): 527-532.
- [8]. Thanh DD, et al. The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells. Sci Rep. 2024 Dec 5;14(1):30367. [Content Brief]
- [9]. Soares BM, et al. Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Anticancer Res. 2015 Mar;35(3):1465-74. [Content Brief]
- [10]. Haridevamuthu B, Murugan R, Seenivasan B, Meenatchi R, Pachaiappan R, Almutairi BO, Arokiyaraj S, M K K, et al. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. J Hazard Mater. 2024 Jan 5;461:132524. [Content Brief]
- [11]. Gao Y, et al. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. J Food Sci. 2011 Aug;76(6):T125-9. [Content Brief]
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