194085-75-1
194085-75-1
Chemical Structure
Carisbamate
Synonym(s): RWJ-333369
- CAS. Nr.: 194085-75-1
- Formula:C9H10ClNO3
- Molecular Weight:215.64
IUPAC Name: (S)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
InChIKey: OLBWFRRUHYQABZ-MRVPVSSYSA-N
SMILES: NC(OC[C@H](C1=CC=CC=C1Cl)O)=O
Biological Activity: Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Carisbamate | 98.75% | Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy. | ||||||||||||||||||||
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Carisbamate-d4 | Carisbamate-d4 is the deuterium labeled Carisbamate. | |||||||||||||||||||||
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(R)-Carisbamate-d4 | (R)-Carisbamate-d4 is the deuterium labeled (R)-Carisbamate. | |||||||||||||||||||||
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Carisbamate-d215N | Carisbamate-d2,-15N (RWJ-333369-d2,-15N) is the deuterium labeled Carisbamate (HY-14948). Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy. | |||||||||||||||||||||
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(Rac)-Carisbamate-d4 | (Rac)-Carisbamate-d4 is deuterium labeled Carisbamate. | |||||||||||||||||||||
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References
- [1]. Deshpande LS, et al. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons. Epilepsia. 2008 Oct;49(10):1795-802. [Content Brief]
- [2]. François J, et al. Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS. Epilepsia. 2008 Mar;49(3):393-9. [Content Brief]
- [3]. Novak GP, et al. Carisbamate (RWJ-333369). Neurotherapeutics. 2007 Jan;4(1):106-9. [Content Brief]
