2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. SCH 54388

SCH 54388 is an orally active metabolite of Felbamate (HY-B0184). SCH 54388 significantly attenuates the functional impairment effects induced by Scopolamine (HY-N0296) or Dizocilpine (HY-15084B). SCH 54388 can be used in research related to cognitive impairment.

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SCH 54388

SCH 54388 Chemical Structure

CAS No. : 25451-53-0

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SCH 54388 Related Antibodies

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Description

SCH 54388 is an orally active metabolite of Felbamate (HY-B0184). SCH 54388 significantly attenuates the functional impairment effects induced by Scopolamine (HY-N0296) or Dizocilpine (HY-15084B). SCH 54388 can be used in research related to cognitive impairment[1].

In Vivo

SCH 54388 (0.1-10 mg/kg; s.c. or p.o.; single administration) reverses scopolamine-induced cognitive impairment in BALB mice[1].
SCH 54388 (0.01-0.1 mg/kg; s.c.; single administration) reverses dizocilpine-induced cognitive impairment in CF-1 mice[1].
SCH 54388 (10-100 mg/kg; s.c.; single administration) produces statistically significant analgesic effects in CF-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)[1]
Dosage: 0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
Administration: s.c.; single dose
Result: Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.
Animal Model: Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)[1]
Dosage: 0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
Administration: p.o.; single dose
Result: Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.
Animal Model: Charles River CF-1 (male, 25-30 g, dizocilpine-induced cognitive impairment)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg
Administration: s.c.; single dose
Result: Produced mean reentry latencies statistically greater than dizocilpine alone.
Demonstrated a statistically significant overall treatment effect.
Animal Model: Charles River CF-1 (male, 25-30 g)[1]
Dosage: 10 mg/kg; 100 mg/kg
Administration: s.c.; single dose
Result: Produced statistically significant increases in mean escape jump latencies compared to vehicle-treated animals.
Molecular Weight

195.22

Formula

C10H13NO3
CAS No.
SMILES

O=C(N)OCC(CO)C1=CC=CC=C1
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCH 54388 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 5438825451-53-0SCH54388SCH-54388Drug MetaboliteNMDA receptorintracellular Ca2+ influxpassive-avoidance response deficitsCF-1 micefelbamatescopolaminedizocilpinemiceBALB micecognitive deficitInhibitorinhibitorinhibit

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