1942919-63-2
1942919-63-2
Chemical Structure
ABCG2-IN-3
- CAS. Nr.: 1942919-63-2
- Formula:C25H20Cl2N2O2
- Molecular Weight:451.34
IUPAC Name: (1-(3,4-dichlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)(4-methoxyphenyl)methanone
InChIKey: AKQFVWUCZTWDKB-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C(N2C(C3=C(CC2)C(C=CC=C4)=C4N3)C5=CC(Cl)=C(C=C5)Cl)=O
Biological Activity: ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1].
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ABCG2-IN-3 | ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity. | |||||||||||||||||||||
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