1948-31-8
1948-31-8
Chemical Structure
H-Ala-Ala-OH
Synonym(s): L-Alanyl-L-alanine; Ala-Ala
- CAS No.: 1948-31-8
- Formula:C6H12N2O3
- Molecular Weight:160.17
IUPAC Name: L-alanyl-L-alanine
InChIKey: DEFJQIDDEAULHB-IMJSIDKUSA-N
SMILES: C[C@@H](C(O)=O)NC([C@H](C)N)=O
Biological Activity:
H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC50 of 0.25 mM and an EC50 of 0.08 mM against human PEPT1. When used as a dipeptide linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release[1][2][3].
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H-Ala-Ala-OH | 98.0% | H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC50 of 0.25 mM and an EC50 of 0.08 mM against human PEPT1. When used as a dipeptide linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release. |
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H-Ala-Ala-OH (Standard) | ≥98% | H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) (Standard) is the analytical standard of H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala). This product is intended for research and analytical applications. H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification. | ||||||||||||||||||||
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References
- [1]. Wang L, et al. Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide. RSC Med Chem. 2023;15(1):355-365. Published 2023 Nov 27. [Content Brief]
- [2]. Vig BS, et al. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006;49(12):3636-3644. [Content Brief]
- [3]. Covitz KM, et al. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res. 1996;13(11):1631-1634. [Content Brief]
