195054-99-0
195054-99-0
Chemical Structure
NBI 30545
- CAS No.: 195054-99-0
- Formula:C22H30N4O3
- Molecular Weight:398.51
IUPAC Name: 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
InChIKey: AKFWXFDMKRSYRD-UHFFFAOYSA-N
SMILES: N1=C(C=C(N2N=C(C(=C12)C=3C=CC(OC)=CC3OC)C)N(CCOC)CCC)C
Biological Activity: NBI 30545 is a blood-brain barrier permeable CRF1R antagonist with a Ki value of 3.4 nM for the human receptor. NBI 30545 inhibits CRF-stimulated intracellular cAMP accumulation and ACTH release. NBI 30545 can be used in the research of depression, anxiety disorders and stress-related diseases[1].
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NBI 30545 | NBI 30545 is a blood-brain barrier permeable CRF1R antagonist with a Ki value of 3.4 nM for the human receptor. NBI 30545 inhibits CRF-stimulated intracellular cAMP accumulation and ACTH release. NBI 30545 can be used in the research of depression, anxiety disorders and stress-related diseases. | |||||||||||||||||||||
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