1966107-70-9
Chemical Structure
DC-34
- CAS No.: 1966107-70-9
- Formula:C24H25F3N2O3
- Molecular Weight:446.47
IUPAC Name: 4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-3-carboxamide
InChIKey: CCAKHVBCBLIIEV-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)C(F)(F)F)C2=C(OC3=CC=C(O)C(=C32)CN4CCCCCC4)C
Biological Activity: DC-34 is a selective stabilizer of MYC G-quadruplexes (G4s), with measured Kd values of 9.4 μM (FIA), 1.4 μM (SPR), and 16.5 μM (NMR) across different assays. DC-34 downregulates MYC levels in cancer cells in a G4-dependent manner, reduces cell viability, and induces G0-G1 cell cycle arrest and p16-marked senescence in MYC-driven multiple myeloma cells. DC-34 can serve as a probe for G4-dependent gene regulation studies and is applicable to research on multiple myeloma[1].
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DC-34 | DC-34 is a selective stabilizer of MYC G-quadruplexes (G4s), with measured Kd values of 9.4 μM (FIA), 1.4 μM (SPR), and 16.5 μM (NMR) across different assays. DC-34 downregulates MYC levels in cancer cells in a G4-dependent manner, reduces cell viability, and induces G0-G1 cell cycle arrest and p16-marked senescence in MYC-driven multiple myeloma cells. DC-34 can serve as a probe for G4-dependent gene regulation studies and is applicable to research on multiple myeloma. | |||||||||||||||||||||
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Keywords
