2011034-35-6
Chemical Structure
UNC3133
- CAS No.: 2011034-35-6
- Formula:C30H44N6O
- Molecular Weight:504.71
IUPAC Name: 15-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-17H-2-aza-1(2,7)-pyrrolo[2,3-d]pyrimidinacyclotetradecaphan-10-ol
InChIKey: LZOJVTCTBSNNNT-UHFFFAOYSA-N
SMILES: OC(CCCCCCCN1)CCCCN2C3=NC1=NC=C3C(C4=CC=C(C=C4)CN5CCN(CC5)C)=C2
Biological Activity: UNC3133 is an orally active, limitedly selective MerTK inhibitor with an IC50 of 3.0 nM. UNC3133 inhibits Axl, Tyro3 and Flt3 kinases, with IC50 values of 17 nM, 31 nM and 6.8 nM, respectively. UNC3133 is applicable to the research of inflammatory diseases and cancers[1].
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UNC3133 | UNC3133 is an orally active, limitedly selective MerTK inhibitor with an IC50 of 3.0 nM. UNC3133 inhibits Axl, Tyro3 and Flt3 kinases, with IC50 values of 17 nM, 31 nM and 6.8 nM, respectively. UNC3133 is applicable to the research of inflammatory diseases and cancers. | |||||||||||||||||||||
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Keywords
