2012563-34-5
Chemical Structure
Mcl1-IN-7
- CAS No.: 2012563-34-5
- Formula:C36H34BN3O7
- Molecular Weight:631.48
IUPAC Name: 7-(3-((4-borono-3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-1-methyl-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
InChIKey: MUZZYPOVNNFUHN-UHFFFAOYSA-N
SMILES: O=CC1=CC(OCC2=NN(C)C(C)=C2C3=CC=CC4=C3N(C)C(C(O)=O)=C4CCCOC5=CC=CC6=C5C=CC=C6)=CC=C1B(O)O
Biological Activity: Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.
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Mcl1-IN-7 | Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena. | |||||||||||||||||||||
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Keywords
