20229-30-5
20229-30-5
Chemical Structure
Methiothepin
Synonym(s): Metitepine; Ro 8-6837
- CAS No.: 20229-30-5
- Formula:C20H24N2S2
- Molecular Weight:356.55
IUPAC Name: 1-methyl-4-(8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine
InChIKey: RLJFTICUTYVZDG-UHFFFAOYSA-N
SMILES: CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1
Biological Activity: Methiothepin (Metitepine; Ro 8-6837) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Methiothepin | Methiothepin (Metitepine; Ro 8-6837) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
