205187-53-7
205187-53-7
Chemical Structure
CX-157
- CAS No.: 205187-53-7
- Formula:C14H8F4O4S
- Molecular Weight:348.27
IUPAC Name: 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
InChIKey: PDIMOTRDGUQMNY-UHFFFAOYSA-N
SMILES: FC(F)(F)COC1=CC(OC2=CC(F)=CC=C2S3(=O)=O)=C3C=C1
Biological Activity: CX-157 is an orally active and blood-brain barrier-penetrant selective monoamine oxidase-A inhibitor. CX-157 competitively inhibits monoamine oxidase-A to reduce monoamine catabolism, thereby elevating brain levels of Serotonin, Norepinephrine, and Dopamine. CX-157 can be used for research on major depressive disorder[1][2].
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CX-157 | 99.76% | CX-157 is an orally active and blood-brain barrier-penetrant selective monoamine oxidase-A inhibitor. CX-157 competitively inhibits monoamine oxidase-A to reduce monoamine catabolism, thereby elevating brain levels of Serotonin, Norepinephrine, and Dopamine. CX-157 can be used for research on major depressive disorder. | ||||||||||||||||||||
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References
- [1]. Targum SD. Early symptomatic improvement affects treatment outcome in a study of major depressive disorder. J Psychiatr Res. 2017 Dec;95:276-281.
- [2]. Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31. [Content Brief]
