20776-45-8
Chemical Structure
5-Benzyloxytryptamine
Synonym(s): 5-BT
- CAS. Nr.: 20776-45-8
- Formula:C17H18N2O
- Molecular Weight:266.34
IUPAC Name: 2-(5-(benzyloxy)-1H-indol-3-yl)ethan-1-amine
InChIKey: WKPDXBXNJWWWGQ-UHFFFAOYSA-N
SMILES: NCCC1=CNC2=CC=C(OCC3=CC=CC=C3)C=C12
Biological Activity: 5-Benzyloxytryptamine (5-BT) is a selective partial agonist for 5-hydroxytryptamine 1D/1B (5-HT1D/1B) receptors with an IC50 value of 40 nM for bovine caudate 5-HT1D and reduced affinity for other receptors (5-HT2 IC50>470 nM). 5-Benzyloxytryptamine inhibits adenylate cyclase to decrease neurotransmitter release and downregulate cAMP signaling. 5-Benzyloxytryptamine is promising for research of neurotransmitter imbalance-related disorders like migraine[1].
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5-Benzyloxytryptamine | 5-Benzyloxytryptamine (5-BT) is a selective partial agonist for 5-hydroxytryptamine 1D/1B (5-HT1D/1B) receptors with an IC50 value of 40 nM for bovine caudate 5-HT1D and reduced affinity for other receptors (5-HT2 IC50>470 nM). 5-Benzyloxytryptamine inhibits adenylate cyclase to decrease neurotransmitter release and downregulate cAMP signaling. 5-Benzyloxytryptamine is promising for research of neurotransmitter imbalance-related disorders like migraine. | |||||||||||||||||||||
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