2092914-16-2
Chemical Structure
TC9-305
- CAS No.: 2092914-16-2
- Formula:C33H37F3N4O6S
- Molecular Weight:674.73
IUPAC Name: N-(adamantan-1-yl)-4-((4-(1-(3,4-dimethoxybenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-6-(trifluoromethyl)pyrimidin-2-yl)sulfonyl)butanamide
InChIKey: GQVPWRCSKOKXLO-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=NC(S(CCCC(NC34CC5CC(CC(C4)C5)C3)=O)(=O)=O)=NC(C(F)(F)F)=C2)=CN1CC6=CC=C(C(OC)=C6)OC
Biological Activity: TC9-305 is a potent and selective apoptosis inhibitor. TC9-305 has strong inhibitory activity against both Bim and tBid-induced apoptosis with EC50 values of 0.42 and 0.23 μM. TC9-305 can maintain the mitochondrial membrane potential, reduce ROS production, prevent the release of cytochrome c and block the upstream pathways of mitochondrial-mediated apoptosis. TC9-305 can be used for the research of neurological disease, such as storke[1].
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TC9-305 | TC9-305 is a potent and selective apoptosis inhibitor. TC9-305 has strong inhibitory activity against both Bim and tBid-induced apoptosis with EC50 values of 0.42 and 0.23 μM. TC9-305 can maintain the mitochondrial membrane potential, reduce ROS production, prevent the release of cytochrome c and block the upstream pathways of mitochondrial-mediated apoptosis. TC9-305 can be used for the research of neurological disease, such as storke. | |||||||||||||||||||||
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Keywords
