209969-75-5
Chemical Structure
Paeonidanin
- CAS No.: 209969-75-5
- Formula:C24H30O11
- Molecular Weight:494.49
IUPAC Name: 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-amine oxide
InChIKey: CUOSPKQOVDKAPD-RIXLYZTQSA-N
SMILES: O=C(C1=CC=CC=C1)OC[C@@]2([C@@](C(C[C@@]3(O[C@@H]2OC)C)=O)([H])C4)[C@]43O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO
Biological Activity: Paeonidanin is a monoterpenoid glycoside found in rhizomes of Paeonia lactiflora Pall., roots of Paeonia albiflora, and root cortex of Paeonia suffruticosa Andrews, with an IC50 > 100 μM for nitric oxide production inhibition in lipopolysaccharide-activated microglia and macrophages. Paeonidanin suppresses lipopolysaccharide-induced production of nitric oxide, interleukin-6, and tumor necrosis factor alpha in macrophages and microglia.Paeonidanin can be used for the research of inflammation[1][2][3].
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Paeonidanin | Paeonidanin is a monoterpenoid glycoside found in rhizomes of Paeonia lactiflora Pall., roots of Paeonia albiflora, and root cortex of Paeonia suffruticosa Andrews, with an IC50 > 100 μM for nitric oxide production inhibition in lipopolysaccharide-activated microglia and macrophages. Paeonidanin suppresses lipopolysaccharide-induced production of nitric oxide, interleukin-6, and tumor necrosis factor alpha in macrophages and microglia.Paeonidanin can be used for the research of inflammation. | |||||||||||||||||||||
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- [1]. Bi X, et al. Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells. Molecules (Basel, Switzerland). 2017 Apr 29;22(5):715. [Content Brief]
- [2]. Duan WJ, et al. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. Journal of natural products. 2009 Sep;72(9):1579-84. [Content Brief]
- [3]. Ding L, et al. New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells. Bioorganic & medicinal chemistry letters. 2012 Dec 01;22(23):7243-7. [Content Brief]
Keywords
