Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia

  • J Nat Prod. 2009 Sep;72(9):1579-84. doi: 10.1021/np9001898.
Wen-Juan Duan  1 ,  Jing-Yu Yang ,  Li-Xia Chen ,  Li-Jia Zhang ,  Zhi-Hu Jiang ,  Xu-Dong Cai ,  Xue Zhang ,  Feng Qiu
Affiliations
  • 1. Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University 81, No. 103 Road WenHua, Shenyang, People's Republic of China.
PMID: 19691309 DOI: 10.1021/np9001898
Abstract

Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), paeonidanin B (3), paeonidanin C (4), paeonidanin D (5), paeonidanin E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of the roots of Paeonia albiflora. Their structures were determined primarily on the basis of 1D and 2D NMR techniques and MS studies. Paeonidanins D (5) and E (6) are unprecedented examples of "cage-like" monoterpene dimers. The inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (LPS)-activated N9 microglia were evaluated.

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