Paeonidanin
Paeonidanin is a monoterpenoid glycoside found in rhizomes of Paeonia lactiflora Pall., roots of Paeonia albiflora, and root cortex of Paeonia suffruticosa Andrews, with an IC50 > 100 μM for nitric oxide production inhibition in lipopolysaccharide-activated microglia and macrophages. Paeonidanin suppresses lipopolysaccharide-induced production of nitric oxide, interleukin-6, and tumor necrosis factor alpha in macrophages and microglia.Paeonidanin can be used for the research of inflammation.
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- CAS No.: 209969-75-5
- Formule: C24H30O11
- Masse moléculaire:494.49
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Stockage:
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| N9 | IC50 |
>100 μM
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Inhibition of nitric oxide production in lipopolysaccharide-activated murine N9 microglial cells assessed via Griess reaction after 48 h incubation with Paeonidanin.
Inhibition of nitric oxide production in lipopolysaccharide-activated murine N9 microglial cells assessed via Griess reaction after 48 h incubation with Paeonidanin.
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19691309 |
Paeonidanin (PD) (33 μM; 2 h) potently inhibits LPS-induced NO production in RAW 264.7 cells[1].
Paeonidanin (11-100 μM; 2 h) inhibits LPS-induced TNF-α production in RAW 264.7 cells in a dose-dependent manner, with the strongest effect at 100 μM[1].
Paeonidanin (11-100 μM; 2 h) inhibits LPS-induced IL-6 production in RAW 264.7 cells in a dose-dependent manner, with significant effects at 33 and 100 μM[1].
Paeonidanin (100 μM; 2 h) exhibits no cytotoxicity toward RAW 264.7 cells, with or without LPS stimulation[1].
Paeonidanin (compound 1) (1.0-30.0 μM; 48 h) exhibits weak inhibitory activity on nitric oxide production in LPS-activated N9 microglial cells, with significant inhibition only at 10.0 μM and 30.0 μM, and an IC50 greater than 100 μM[2].
Paeonidanin (compound 11) (> 100 μM) does not inhibit NO production in LPS-induced RAW 264.7 macrophages, with an IC50 > 100 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophages
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Concentration:11, 33, 100 μM
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Incubation Time:2 h
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Result:Inhibited LPS-induced TNF-α production in a dose-dependent manner.
Significantly reduced TNF-α production at 33 μM.
Exhibited even stronger inhibition at 100 μM.
Inhibited LPS-induced IL-6 production in a dose-dependent manner.
Significantly reduced IL-6 production at 33 and 100 μM.
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Cell Line:RAW 264.7 macrophages
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Concentration:100 μM
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Incubation Time:2 h
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Result:Showed no obvious cytotoxicity on RAW 264.7 cells at the tested concentration of 100 μM, regardless of LPS stimulation.
Chemical Information
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CAS No. 209969-75-5
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Masse moléculaire 494.49
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Formule C24H30O11
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SMILES
O=C(C1=CC=CC=C1)OC[C@@]2([C@@](C(C[C@@]3(O[C@@H]2OC)C)=O)([H])C4)[C@]43O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Bi X, et al. Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells. Molecules (Basel, Switzerland). 2017 Apr 29;22(5):715. [Content Brief]
[2]. Duan WJ, et al. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. Journal of natural products. 2009 Sep;72(9):1579-84. [Content Brief]
[3]. Ding L, et al. New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells. Bioorganic & medicinal chemistry letters. 2012 Dec 01;22(23):7243-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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