2101517-69-3
2101517-69-3
Chemical Structure
BL-918
- CAS No.: 2101517-69-3
- Formula:C23H15F8N3OS
- Molecular Weight:533.44
IUPAC Name: (R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-(2,4-difluorophenyl)-2-phenylacetamide
InChIKey: BDBWQANRZRCMMD-LJQANCHMSA-N
SMILES: O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=S)C3=CC=CC=C3
Biological Activity: BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC50 of 24.14 nM. BL-918 exerts its cytoprotective autophagic effect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) treatment[1].
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BL-918 | 99.72% | BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC50 of 24.14 nM. BL-918 exerts its cytoprotective autophagic effect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) treatment. | ||||||||||||||||||||
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References
Keywords
