210890-55-4
Chemical Structure
Dermaseptin-B3
- CAS No.: 210890-55-4
- Formula:C127H219N35O32S
- Molecular Weight:2780.38
SMILES: C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)[C@H](C)C)=O)CC(C)C)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)C)=O)C)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(N)=O)=O)=O)C)=O)CC(C)C)=O)CCCCN)=O)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CC(C)C)=O)CCSC)=O)CC(N)=O)=O)CCCCN)=O)NC([C@@H](NC([C@H](C)N)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2
Biological Activity: Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation[1][2].
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Dermaseptin-B3 | Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation. | |||||||||||||||||||||
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References
- [1]. Charpentier S, et al. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics. J Biol Chem. 1998 Jun 12;273(24):14690-7. [Content Brief]
- [2]. van Zoggel H, et al . Antitumor and angiostatic peptides from frog skin secretions. Amino Acids. 2012 Jan;42(1):385-95. [Content Brief]
