2109805-65-2
Chemical Structure
PDE5-IN-1
- CAS No.: 2109805-65-2
- Formula:C22H14N2O4S
- Molecular Weight:402.42
IUPAC Name: 3-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(thiazol-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one
InChIKey: ZUGQSSCMJHOUMY-UHFFFAOYSA-N
SMILES: O=C1C=2C=CC=CC2OC=3C1=C(NC3CC4=CC=C5OCOC5=C4)C6=NC=CS6
Biological Activity: PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5, and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension[1].
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PDE5-IN-1 | PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5, and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension. | |||||||||||||||||||||
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Keywords
