2110-25-0
Chemical Structure
UCCF-029 free base
- CAS No.: 2110-25-0
- Formula:C18H11NO2
- Molecular Weight:273.29
IUPAC Name: 2-(pyridin-4-yl)-4H-benzo[h]chromen-4-one
InChIKey: LZCOBWKVDSSOBB-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=NC=C2)OC3=C1C=CC4=C3C=CC=C4
Biological Activity: UCCF-029 Free base is a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. UCCF-029 Free base exhibits enhanced activity through benzannulation of the flavone A-ring at the 7,8-position. UCCF-029 Free base serves as a structural guide for the development of more effective flavonoid analogues. UCCF-029 Free base demonstrates improved potency compared to apigenin in activating wild-type CFTR. UCCF-029 Free base also exhibits potential for activating the mutant CFTR (G551D-CFTR) though not as robustly as apigenin.
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UCCF-029 free base | UCCF-029 Free base is a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. UCCF-029 Free base exhibits enhanced activity through benzannulation of the flavone A-ring at the 7,8-position. UCCF-029 Free base serves as a structural guide for the development of more effective flavonoid analogues. UCCF-029 Free base demonstrates improved potency compared to apigenin in activating wild-type CFTR. UCCF-029 Free base also exhibits potential for activating the mutant CFTR (G551D-CFTR) though not as robustly as apigenin. | |||||||||||||||||||||
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