2116468-11-0
2116468-11-0
Chemical Structure
J208
- CAS No.: 2116468-11-0
- Formula:C20H24N6O4
- Molecular Weight:412.44
InChIKey: VMUQPDRCKFICAG-UHFFFAOYSA-N
SMILES: O=C1C=CN(C(N1)=O)CC2=CC=C(C=C2)C3=CN(N=N3)CCCCCCC(NO)=O
Biological Activity: J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs)[1].
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J208 | J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs). | |||||||||||||||||||||
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