212391-63-4
212391-63-4
Chemical Structure
PD0166285 dihydrochloride
- CAS No.: 212391-63-4
- Formula:C26H29Cl4N5O2
- Molecular Weight:585.35
IUPAC Name: 6-(2,6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
InChIKey: NADLBPWBFGTESN-UHFFFAOYSA-N
SMILES: O=C1N(C)C2=NC(NC3=CC=C(OCCN(CC)CC)C=C3)=NC=C2C=C1C4=C(Cl)C=CC=C4Cl.[H]Cl.[H]Cl
Biological Activity: PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1[1].
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PD0166285 dihydrochloride | PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1. | |||||||||||||||||||||
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PD-166285-d4 | PD-166285-d4 is the deuterium labeled PD-166285. | |||||||||||||||||||||
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References
