2128304-65-2
2128304-65-2
Chemical Structure
PDSinh-C01
- CAS No.: 2128304-65-2
- Formula:C20H23N3O2S2
- Molecular Weight:401.55
InChIKey: JVSKXVULCIYOPZ-UHFFFAOYSA-N
SMILES: CC1=NNC(C2=CC(S(NC3C(C=CC=C4)=C4CCC3)(=O)=O)=C(C)S2)=C1C
Biological Activity: PDSinh-C01 is a reversible, non-competitive pendrin (SLC26A4) inhibitor with an IC50 of 2.5 μM. PDSinh-C01 inhibits pendrin-mediated Cl−/SCN− exchange activity, reduces cell counts, protein levels, and pro-inflammatory cytokine production in bronchoalveolar lavage fluid. PDSinh-C01 can be used in research related to acute lung injury and cystic fibrosis[1][2].
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PDSinh-C01 | PDSinh-C01 is a reversible, non-competitive pendrin (SLC26A4) inhibitor with an IC50 of 2.5 μM. PDSinh-C01 inhibits pendrin-mediated Cl−/SCN− exchange activity, reduces cell counts, protein levels, and pro-inflammatory cytokine production in bronchoalveolar lavage fluid. PDSinh-C01 can be used in research related to acute lung injury and cystic fibrosis. | |||||||||||||||||||||
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References
- [1]. Choi HK, et al. The comparison of two pendrin inhibitors, YS-01 and PDSinh-C01, in lipopolysaccharide-induced acute lung injury. Scientific reports. 2026 Jun 23. [Content Brief]
- [2]. Lipani A, et al. Modulators of anion channels and transporters as alternative therapeutic agents to normalize airway surface liquid in cystic fibrosis. European journal of medicinal chemistry. 2026 Jan 15;302(Pt 2):118325. [Content Brief]
Keywords
