215303-72-3
215303-72-3
Chemical Structure
RWJ-67657
Synonym(s): JNJ 3026582
- CAS No.: 215303-72-3
- Formula:C27H24FN3O
- Molecular Weight:425.50
IUPAC Name: 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol
InChIKey: QSUSKMBNZQHHPA-UHFFFAOYSA-N
SMILES: OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4
Biological Activity: RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RWJ-67657 | 99.75% | RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity. | ||||||||||||||||||||
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RWJ-67657 (Standard) | ≥98% | RWJ-67657 (Standard) is the analytical standard of RWJ-67657. This product is intended for research and analytical applications. RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-105480SKF 104351 -
Similarity Score 0.58
HY-175430TNF-α-IN-26 -
Similarity Score 0.56
HY-183533Cytokine-IN-1 -
Similarity Score 0.56
HY-183530p38 MAPK-IN-11 -
Similarity Score 0.55
HY-178267p38 MAP Kinase-IN-2 -
Similarity Score 0.54
HY-178214CSBP ligand 1 -
Similarity Score 0.54
HY-100115RTA-02 (Standard) -
Similarity Score 0.54
HY-178209p38 MAP Kinase-IN-3 -
Similarity Score 0.53
HY-175433p38 MAPK-IN-10 -
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