2163769-52-4
2163769-52-4
Chemical Structure
BAY-155
- CAS No.: 2163769-52-4
- Formula:C28H28F3N7OS
- Molecular Weight:567.63
InChIKey: KMCCLTBDFVCDLQ-UHFFFAOYSA-N
SMILES: O=C(N)CN1C(C#N)=CC2=C1C=CC(CN(CC3)CCC43CN(C5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)C4)=C2C
Biological Activity: BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models[1].
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BAY-155 | BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models. | |||||||||||||||||||||
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References
Keywords
