217317-45-8
217317-45-8
Chemical Structure
21H7
- CAS No.: 217317-45-8
- Formula:C18H14BrN3O2
- Molecular Weight:384.23
InChIKey: MTVVJOBPGQXHML-KEBDBYFISA-N
SMILES: O=C(C1=CC(C)=NC2=C1C=C(Br)C=C2)N/N=C/C3=C(O)C=CC=C3
Biological Activity: 21H7 is a selective inhibitor of the Wnt/b-catenin pathway. 21H7 markedly inhibits the growth of HFs. 21H7 potently decreases growth of breast and colon cancer cells[1][2].
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21H7 | 21H7 is a selective inhibitor of the Wnt/b-catenin pathway. 21H7 markedly inhibits the growth of HFs. 21H7 potently decreases growth of breast and colon cancer cells. | |||||||||||||||||||||
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References
- [1]. Chang M, et al. PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation. Mol Cancer Ther. 2010 Sep;9(9):2478-87. [Content Brief]
- [2]. Bao R, et al. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS One. 2012;7(11):e48670. [Content Brief]
Keywords
