2196246-28-1
Chemical Structure
USP7-IN-20
- CAS No.: 2196246-28-1
- Formula:C22H24BrN3O3S
- Molecular Weight:490.41
InChIKey: NRRXSEFLOFZNSO-OAHLLOKOSA-N
SMILES: O=C1C2=C(C(Br)=CS2)N=CN1CC3(CCN(CC3)C(C[C@H](C4=CC=CC=C4)C)=O)O
Biological Activity: USP7-IN-20 is a highly selective USP7 inhibitor that binds allosterically to the allosteric pocket of USP7 in a non-competitive and reversible manner. USP7-IN-20 downregulates MDM2 protein levels and stabilizes p53, thereby inducing p21 expression and enhancing the ubiquitin-dependent degradation of MDM2. USP7-IN-20 effectively binds endogenous USP7 to inhibit cancer cell proliferation, and also induces apoptosis by promoting the cleavage of PARP and caspase 3. USP7-IN-20 can be widely used in cancer-related basic and translational research.[1]
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USP7-IN-20 | USP7-IN-20 is a highly selective USP7 inhibitor that binds allosterically to the allosteric pocket of USP7 in a non-competitive and reversible manner. USP7-IN-20 downregulates MDM2 protein levels and stabilizes p53, thereby inducing p21 expression and enhancing the ubiquitin-dependent degradation of MDM2. USP7-IN-20 effectively binds endogenous USP7 to inhibit cancer cell proliferation, and also induces apoptosis by promoting the cleavage of PARP and caspase 3. USP7-IN-20 can be widely used in cancer-related basic and translational research. | |||||||||||||||||||||
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