219649-95-3
Chemical Structure
Griffipavixanthone
Synonym(s): (+)-Griffipavixanthone
- CAS No.: 219649-95-3
- Formula:C36H28O12
- Molecular Weight:652.60
IUPAC Name: (8R,8aR,12aS)-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-8a,9,10,12a-tetrahydroindeno[1,2-a]xanthen-13(8H)-one
InChIKey: KAPVRSRPLHVWCH-CVKDPSGVSA-N
SMILES: OC1=C(O)C(OC2=CC(O)=CC(O)=C2C3=O)=C3C4=C1[C@@H](C5=C6C(OC7=CC(O)=CC(O)=C7C6=O)=C(C(O)=C5)O)[C@@]8([H])[C@]4([H])C=C(C)CC8(C)C
Biological Activity: Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM)[1][2][3].
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Griffipavixanthone | Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM). | |||||||||||||||||||||
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- [1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. [Content Brief]
- [2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. [Content Brief]
- [3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. [Content Brief]
Keywords
