220060-39-9
220060-39-9
Chemical Structure
Thioquinapiperifil
Synonym(s): KF31327 free base
- CAS No.: 220060-39-9
- Formula:C24H28N6OS
- Molecular Weight:448.58
IUPAC Name: 3-ethyl-8-((2-(4-(hydroxymethyl)piperidin-1-yl)benzyl)amino)-1,3-dihydro-2H-imidazo[4,5-g]quinazoline-2-thione
InChIKey: NMKUPEWPVORTPC-UHFFFAOYSA-N
SMILES: S=C1NC2=CC3=C(NCC4=CC=CC=C4N5CCC(CO)CC5)N=CN=C3C=C2N1CC
Biological Activity: Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].
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Thioquinapiperifil | Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study. | |||||||||||||||||||||
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References
- [1]. Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. [Content Brief]
- [2]. R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. [Content Brief]
