1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Thioquinapiperifil

Thioquinapiperifil  (Synonyms: KF31327 free base)

Cat. No.: HY-119611
Handling Instructions

Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Thioquinapiperifil dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Thioquinapiperifil Chemical Structure

Thioquinapiperifil Chemical Structure

CAS No. : 220060-39-9

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Description

Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].

IC50 & Target[2]

PDE5

0.074 nM (IC50)

PDE1

380 nM (IC50)

PDE2

670 nM (IC50)

PDE3

38 nM (IC50)

PDE4

800 nM (IC50)

In Vitro

Thioquinapiperifil can be found in dietary supplements[1].
Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation[2].
Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/108 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

448.58

Formula

C24H28N6OS

CAS No.
SMILES

S=C1NC2=CC3=C(NCC4=CC=CC=C4N5CCC(CO)CC5)N=CN=C3C=C2N1CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Thioquinapiperifil Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Thioquinapiperifil
Cat. No.:
HY-119611
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