220747-81-9
220747-81-9
Chemical Structure
Buspirone N-oxide
Synonym(s): Bu N-oxide
- CAS No.: 220747-81-9
- Formula:C21H31N5O3
- Molecular Weight:401.50
IUPAC Name: 1-(4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl)-4-(pyrimidin-2-yl)piperazine 1-oxide
InChIKey: PXFOIYSPRVISSG-UHFFFAOYSA-N
SMILES: O=C(N(CCCC[N+]1([O-])CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4
Biological Activity: Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1][2].
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Buspirone N-oxide | Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research. | |||||||||||||||||||||
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References
- [1]. Zhu M, et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7. [Content Brief]
- [2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. [Content Brief]
