220941-93-5
220941-93-5
Chemical Structure
CP 226269
- CAS No.: 220941-93-5
- Formula:C18H19FN4
- Molecular Weight:310.37
IUPAC Name: 5-fluoro-2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-indole
InChIKey: PQOIDBZLMJMYCD-UHFFFAOYSA-N
SMILES: FC1=CC2=C(C=C1)NC(CN3CCN(CC3)C4=NC=CC=C4)=C2
Biological Activity: CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32 nM. CP 226269 stimulates phospholipid methylation (PLM) in SK-N-MC neuroblastoma cells with an EC50 of 2.9 nM. CP 226269 can be used in the research of schizophrenia and other related diseases[1][2][3].
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CP 226269 | 99.65% | CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32 nM. CP 226269 stimulates phospholipid methylation (PLM) in SK-N-MC neuroblastoma cells with an EC50 of 2.9 nM. CP 226269 can be used in the research of schizophrenia and other related diseases. | ||||||||||||||||||||
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References
- [1]. Sharma A, et al. D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Mol Psychiatry. 1999 May;4(3):235-46. [Content Brief]
- [2]. Robert B Moreland, et al. Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5). Biochem Pharmacol. 2004 Aug 15;68(4):761-72. [Content Brief]
- [3]. Zhang K, et al. Role of dopamine D(4) receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats. Neuropsychopharmacology. 2001 Nov;25(5):624-32. [Content Brief]
