221055-89-6
Chemical Structure
Abz-HPGGPQ-EDDnp
Synonym(s): Cathepsin K substrate
- CAS No.: 221055-89-6
- Formula:C40H50N14O12
- Molecular Weight:918.91
InChIKey: VHIXHCDBFWVSMK-ORYMTKCHSA-N
SMILES: O=C([C@@H](NC(C1=C(N)C=CC=C1)=O)CC2=CNC=N2)N3[C@H](C(NCC(NCC(N4[C@H](C(N[C@H](C(NCCNC5=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C5)=O)CCC(N)=O)=O)CCC4)=O)=O)=O)CCC3
Biological Activity: Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
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Abz-HPGGPQ-EDDnp | Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.) | |||||||||||||||||||||
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