221664-05-7
Chemical Structure
2,3-Dinor-8-iso prostaglandin F 2α
Synonym(s): 2,3-Dinor-8-isoPGF2α
- CAS No.: 221664-05-7
- Formula:C18H30O5
- Molecular Weight:326.43
IUPAC Name: ethyl 7-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate
InChIKey: IDKLJIUIJUVJNR-JSEKUSAISA-N
SMILES: OC(C/C=C\C[C@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O
Biological Activity: 2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes[1][2][3].
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2,3-Dinor-8-iso prostaglandin F 2α | 2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes. | |||||||||||||||||||||
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References
- [1]. Liang Y, et al. Quantification of 8-iso-prostaglandin-F(2alpha) and 2,3-dinor-8-iso-prostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry. Free Radic Biol Med. 2003 Feb 15;34(4):409-18. [Content Brief]
- [2]. Chiabrando C, et al. Identification and measurement of endogenous beta-oxidation metabolites of 8-epi-Prostaglandin F2alpha. J Biol Chem. 1999 Jan 15;274(3):1313-9. [Content Brief]
- [3]. Roberts LJ 2nd, et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J Biol Chem. 1996 Aug 23;271(34):20617-20. [Content Brief]
