2218480-85-2
2218480-85-2
Chemical Structure
NEU-1953
- CAS No.: 2218480-85-2
- Formula:C22H22N8
- Molecular Weight:398.47
IUPAC Name: 7-(2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)-N-(pyrazin-2-yl)quinolin-4-amine
InChIKey: HNQZZUWCYONRSR-UHFFFAOYSA-N
SMILES: N=1C=CN=C(C1)NC=2C=CN=C3C=C(C=CC32)C=4C=NC(=NC4)N5CCN(C)CC5
Biological Activity: NEU-1953 is a parasite inhibitor. NEU-1953 inhibits Abl, EGFR, and KDR tyrosine kinases. NEU-1953 inhibits Aurora A, MNK2, and MAP4K4 serine/threonine kinases. NEU-1953 can be used for research on malaria, human African trypanosomiasis, schistosomiasis, Chagas disease, and leishmaniasis[1][2][3][4].
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NEU-1953 | NEU-1953 is a parasite inhibitor. NEU-1953 inhibits Abl, EGFR, and KDR tyrosine kinases. NEU-1953 inhibits Aurora A, MNK2, and MAP4K4 serine/threonine kinases. NEU-1953 can be used for research on malaria, human African trypanosomiasis, schistosomiasis, Chagas disease, and leishmaniasis. | |||||||||||||||||||||
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References
- [1]. Mehta N, et al. Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation. ACS infectious diseases. 2018 Apr 13;4(4):577-591.
- [2]. Bachovchin KA, et al. Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development. Journal of medicinal chemistry. 2019 Jan 24;62(2):665-687.
- [3]. Buskes MJ, et al. Structure–bioactivity relationships of lapatinib derived analogs against Schistosoma mansoni. ACS Medicinal Chemistry Letters. 2020 Jan 10;11(3):258.
- [4]. Singh B, et al. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS medicinal chemistry letters. 2020 Mar 12;11(3):249-257.
