2222280-82-0
2222280-82-0
Chemical Structure
SHP844
- CAS No.: 2222280-82-0
- Formula:C29H24ClN5O6
- Molecular Weight:573.98
IUPAC Name: (3-chloro-4-((1-(2-hydroxy-3-methoxyphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)benzoyl)-L-proline
InChIKey: SUGSJIDJUCFQEX-QFIPXVFZSA-N
SMILES: O=C(O)[C@H]1N(C(C2=CC=C(CN3C4=NN=C(C5=CC=CC(OC)=C5O)N4C6=C(C=CC=C6)C3=O)C(Cl)=C2)=O)CCC1
Biological Activity: SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival[1].
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SHP844 | SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival. | |||||||||||||||||||||
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References
Keywords
