22242-91-7
Chemical Structure
SLM6
- CAS No.: 22242-91-7
- Formula:C12H17N7O4
- Molecular Weight:323.31
IUPAC Name: 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboximidhydrazide
InChIKey: WAMOLHIDNBDQSK-JTFADIMSSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(C(NN)=N)C3=C(N)N=CN=C32)O1
Biological Activity: SLM6 is a sangivamycin-like molecule. SLM6 is a CDK9 inhibitor. SLM6 inhibits CDK9/cyclin K and CDK9/cyclin T1 kinase activity with IC50s of 280 nM and 133 nM, respectively. SLM6 also inhibits CDK1/cyclin B and CDK2/ cyclin A with IC50s of less than 300 nM. SLM6 induces apoptosis in multiple myeloma (MM) cells[1].
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SLM6 | SLM6 is a sangivamycin-like molecule. SLM6 is a CDK9 inhibitor. SLM6 inhibits CDK9/cyclin K and CDK9/cyclin T1 kinase activity with IC50s of 280 nM and 133 nM, respectively. SLM6 also inhibits CDK1/cyclin B and CDK2/ cyclin A with IC50s of less than 300 nM. SLM6 induces apoptosis in multiple myeloma (MM) cells. | |||||||||||||||||||||
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