2226735-55-1
2226735-55-1
Chemical Structure
GSK547
Synonym(s): GSK'547
- CAS No.: 2226735-55-1
- Formula:C20H18F2N6O
- Molecular Weight:396.39
IUPAC Name: (S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile
InChIKey: SJVGFKBLUYAEOK-SFHVURJKSA-N
SMILES: N#CC1=NC=NC(N2CCC(C(N3N=CC[C@H]3C4=CC(F)=CC(F)=C4)=O)CC2)=C1
Biological Activity: GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer[1].
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GSK547 | 99.92% | GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. | ||||||||||||||||||||
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References
Keywords
