2227279-83-4
2227279-83-4
Chemical Structure
GSK-3 inhibitor 4
- CAS No.: 2227279-83-4
- Formula:C22H15F2N5O
- Molecular Weight:403.38
InChIKey: UWQKULXATKCNBV-UHFFFAOYSA-N
SMILES: O=C(C1=NC(NC2=CC=C(C=C2)F)=NC=C1)NC3=C(C4=CC=C(F)C=C4)C=CN=C3
Biological Activity: GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK-3 inhibitor 4 | 99.02% | GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies. | ||||||||||||||||||||
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