2227372-56-5
2227372-56-5
Chemical Structure
Loreclezole hydrochloride
Synonym(s): R 72063 hydrochloride
- CAS No.: 2227372-56-5
- Formula:C10H7Cl4N3
- Molecular Weight:310.99
IUPAC Name: (Z)-1-(2-chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride
InChIKey: AWKSVFLKVCVVFQ-MDZFRNKHSA-N
SMILES: ClC1=CC=C(/C(Cl)=C/N2N=CN=C2)C(Cl)=C1.[H]Cl
Biological Activity: Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].
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Loreclezole hydrochloride | Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. | |||||||||||||||||||||
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References
- [1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [Content Brief]
- [2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. [Content Brief]
