1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Loreclezole hydrochloride

Loreclezole hydrochloride (Synonyms: R 72063 hydrochloride)

Cat. No.: HY-105272A
Handling Instructions

Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

For research use only. We do not sell to patients.

Loreclezole hydrochloride Chemical Structure

Loreclezole hydrochloride Chemical Structure

CAS No. : 2227372-56-5

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Description

Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

IC50 & Target

GABAA receptor[1].

In Vivo

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3].

Animal Model: Adult male Lister Hooded rats[3].
Dosage: 10, 25, 50 or 75 mg/kg.
Administration: IP, 60 min before measurement of seizure threshold.
Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
Molecular Weight

310.99

Formula

C₁₀H₇Cl₄N₃

CAS No.

2227372-56-5

SMILES

ClC1=CC=C(/C(Cl)=C/N2N=CN=C2)C(Cl)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LoreclezoleR 72063R72063R-72063GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Loreclezole hydrochloride
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