2230826-33-0
Chemical Structure
(R,S,S)-VH032
- CAS No.: 2230826-33-0
- Formula:C22H30N4O3S
- Molecular Weight:430.56
IUPAC Name: (2R,4S)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: ZLOXMSNKPDWMEF-YQVWRLOYSA-N
SMILES: CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O
Biological Activity: (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669)[1].
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(R,S,S)-VH032 | 95.0% | (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669). | ||||||||||||||||||||
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Keywords
