223393-69-9
Chemical Structure
V-165
- CAS No.: 223393-69-9
- Formula:C15H9N5O5S2
- Molecular Weight:403.39
IUPAC Name: 5-(4-nitrophenyl)-2,8-dithioxo-2,3,5,7,8,9-hexahydro-4H-pyrano[2,3-d:6,5-d']dipyrimidine-4,6(1H)-dione
InChIKey: UYLYXNZSRMQYRO-UHFFFAOYSA-N
SMILES: O=C(N1)C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(N3)=O)=C4NC3=S)=C(O4)NC1=S
Biological Activity: V-165 is an inhibitor of HIV Integrase and HIV Reverse transcriptase, with an IC50 value of 3.8 μM against HIV integrase and an IC50 value of 4.8 μM against HIV reverse transcriptase. V-165 inhibits HIV-1 replication. V-165 can be used in studies related to immunodeficiency virus infections[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
V-165 | V-165 is an inhibitor of HIV Integrase and HIV Reverse transcriptase, with an IC50 value of 3.8 μM against HIV integrase and an IC50 value of 4.8 μM against HIV reverse transcriptase. V-165 inhibits HIV-1 replication. V-165 can be used in studies related to immunodeficiency virus infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Pannecouque C, et al. New class of HIV integrase inhibitors that block viral replication in cell culture. Curr Biol. 2002 Jul 23;12(14):1169-77.
- [2]. Hombrouck A, et al. Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action. The Journal of antimicrobial chemotherapy. 2007 Jun;59(6):1084-95.
Keywords
