2245693-15-4
Chemical Structure
TP0480066
- CAS No.: 2245693-15-4
- Formula:C18H14FN3O5
- Molecular Weight:371.32
IUPAC Name: 4-(6-fluoro-4-hydroxy-8-(methylamino)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid
InChIKey: ACSDSFPAGHERCC-UHFFFAOYSA-N
SMILES: CNC1=CC(F)=CC2=C1NC(C(C(NC3=CC=C(C=C3)C(O)=O)=O)=C2O)=O
Biological Activity: TP0480066 is a selective topoisomerase II inhibitor with IC50s of 1.10 and 62.89 nM for DNA gyrase and topo IV, respectively. TP0480066 shows good activity of againsting various bacterial species including drug-resistant strains. TP0480066 also exhibits potent inhibitory activity to N. gonorrhoeae, can be used in study of gonorrhea[1][2].
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TP0480066 | TP0480066 is a selective topoisomerase II inhibitor with IC50s of 1.10 and 62.89 nM for DNA gyrase and topo IV, respectively. TP0480066 shows good activity of againsting various bacterial species including drug-resistant strains. TP0480066 also exhibits potent inhibitory activity to N. gonorrhoeae, can be used in study of gonorrhea. | |||||||||||||||||||||
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- [1]. Ushiyama F, et al. Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115776. [Content Brief]
- [2]. Masuko A, et al. In Vitro and In Vivo Activities of TP0480066, a Novel Topoisomerase Inhibitor, against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02145-20. [Content Brief]
Keywords
